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Phase I study of KRP‐116D, a 50% w/w dimethyl sulfoxide aqueous solution, on the systemic absorption from bladder by intravesical instillation in healthy Japanese subjects

OBJECTIVE: This was a single‐institution, single‐dose, single‐arm phase 1 study in healthy adult males to evaluate the safety and absorption of dimethyl sulfoxide (DMSO) from the bladder into the body when KRP‐116D (a 50% w/w DMSO solution) was intravesically administered and allowed to remain in th...

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Detalles Bibliográficos
Autores principales: Shimada, Hideyo, Yono, Makoto, Hojo, Yuya, Hamamura, Yuka, Ootsuki, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Asia Pty Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217045/
https://www.ncbi.nlm.nih.gov/pubmed/31696635
http://dx.doi.org/10.1111/luts.12295