Structure of the Cannabis sativa olivetol‐producing enzyme reveals cyclization plasticity in type III polyketide synthases

In the native pathway to therapeutic cannabinoid biosynthesis in Cannabis sativa, the three‐step production of a key intermediate, olivetolic acid, is catalysed by the enzymes tetraketide synthase (TKS; linear tetraketide intermediate production in two stages) and olivetolic acid cyclase (OAC; final...

Descripción completa

Detalles Bibliográficos
Autores principales: Kearsey, Lewis J., Prandi, Nicole, Karuppiah, Vijaykumar, Yan, Cunyu, Leys, David, Toogood, Helen, Takano, Eriko, Scrutton, Nigel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Editor's Choice
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217186/
https://www.ncbi.nlm.nih.gov/pubmed/31605668
http://dx.doi.org/10.1111/febs.15089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217186/
https://www.ncbi.nlm.nih.gov/pubmed/31605668
http://dx.doi.org/10.1111/febs.15089

Ejemplares similares