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Structure of the Cannabis sativa olivetol‐producing enzyme reveals cyclization plasticity in type III polyketide synthases

In the native pathway to therapeutic cannabinoid biosynthesis in Cannabis sativa, the three‐step production of a key intermediate, olivetolic acid, is catalysed by the enzymes tetraketide synthase (TKS; linear tetraketide intermediate production in two stages) and olivetolic acid cyclase (OAC; final...

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Detalles Bibliográficos
Autores principales:	Kearsey, Lewis J., Prandi, Nicole, Karuppiah, Vijaykumar, Yan, Cunyu, Leys, David, Toogood, Helen, Takano, Eriko, Scrutton, Nigel S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Editor's Choice
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217186/ https://www.ncbi.nlm.nih.gov/pubmed/31605668 http://dx.doi.org/10.1111/febs.15089

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