Cargando…

Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice

Extensive evidence links Glutamate receptor, ionotropic, NMDA2B (GRIN2B), encoding the GluN2B/NR2B subunit of N-methyl-D-aspartate receptors (NMDARs), with various neurodevelopmental disorders, including autism spectrum disorders (ASDs), but the underlying mechanisms remain unclear. In addition, it...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shin, Wangyong, Kim, Kyungdeok, Serraz, Benjamin, Cho, Yi Sul, Kim, Doyoun, Kang, Muwon, Lee, Eun-Jae, Lee, Hyejin, Bae, Yong Chul, Paoletti, Pierre, Kim, Eunjoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217483/ https://www.ncbi.nlm.nih.gov/pubmed/32353004 http://dx.doi.org/10.1371/journal.pbio.3000717

Ejemplares similares

Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms
por: Kim, Kyungdeok, et al.
Publicado: (2020)

Scn2a Haploinsufficiency in Mice Suppresses Hippocampal Neuronal Excitability, Excitatory Synaptic Drive, and Long-Term Potentiation, and Spatial Learning and Memory
por: Shin, Wangyong, et al.
Publicado: (2019)

NGL-3 in the regulation of brain development, Akt/GSK3b signaling, long-term depression, and locomotive and cognitive behaviors
por: Lee, Hyejin, et al.
Publicado: (2019)

Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation
por: Lee, Eun-Jae, et al.
Publicado: (2015)

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
por: Grand, Teddy, et al.
Publicado: (2018)

GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord
por: Hildebrand, Michael E., et al.
Publicado: (2014)

A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice
por: Yook, Chaehyun, et al.
Publicado: (2019)

GluN2A and GluN2B NMDA receptors use distinct allosteric routes
por: Tian, Meilin, et al.
Publicado: (2021)

Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists
por: Rouzbeh, Nirvan, et al.
Publicado: (2023)

PLPP/CIN regulates bidirectional synaptic plasticity via GluN2A interaction with postsynaptic proteins
por: Kim, Ji-Eun, et al.
Publicado: (2016)

Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming
por: Kim, Hyosang, et al.
Publicado: (2022)

Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation
por: Cummings, Kirstie A., et al.
Publicado: (2016)

Astrocytes increase the activity of synaptic GluN2B NMDA receptors
por: Hahn, Junghyun, et al.
Publicado: (2015)

Palmitoylation at Two Cysteine Clusters on the C-Terminus of GluN2A and GluN2B Differentially Control Synaptic Targeting of NMDA Receptors
por: Mattison, Hayley A., et al.
Publicado: (2012)

Synaptic GluN2A-Containing NMDA Receptors: From Physiology to Pathological Synaptic Plasticity
por: Franchini, Luca, et al.
Publicado: (2020)

Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors
por: Karakas, Erkan, et al.
Publicado: (2011)

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients
por: Mellone, Manuela, et al.
Publicado: (2015)

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity
por: Shipton, Olivia A., et al.
Publicado: (2014)

GluN2B but Not GluN2A for Basal Dendritic Growth of Cortical Pyramidal Neurons
por: Gonda, Steffen, et al.
Publicado: (2020)

Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors
por: Zeng, Yue, et al.
Publicado: (2022)

Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits
por: Cho, Heejin, et al.
Publicado: (2023)

Correction: Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits
por: Cho, Heejin, et al.
Publicado: (2023)

DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors
por: Grau, Cristina, et al.
Publicado: (2014)

Shank3 Mice Carrying the Human Q321R Mutation Display Enhanced Self-Grooming, Abnormal Electroencephalogram Patterns, and Suppressed Neuronal Excitability and Seizure Susceptibility
por: Yoo, Ye-Eun, et al.
Publicado: (2019)

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors
por: Chopra, Divyan A., et al.
Publicado: (2017)

PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function
por: Wang, Yuanyuan, et al.
Publicado: (2020)

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening
por: Talukder, Iehab, et al.
Publicado: (2011)

GluN1 and GluN2A NMDA Receptor Subunits Increase in the Hippocampus during Memory Consolidation in the Rat
por: Cercato, Magali C., et al.
Publicado: (2017)

Mg(2+) block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones
por: Huang, Zhuo, et al.
Publicado: (2014)

d-Serine agonism of GluN1-GluN3 NMDA receptors regulates the activity of enteric neurons and coordinates gut motility
por: Osorio, Nancy, et al.
Publicado: (2023)

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus
por: France, Grace, et al.
Publicado: (2017)

NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content
por: Chiu, Andrew M., et al.
Publicado: (2019)

SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities
por: Zhang, Yanke, et al.
Publicado: (2022)

Effects of morphine and NeuroAid on the expression levels of GluN2A and GluN3A in the hippocampus and striatum of rats
por: Heshmatzad, Katayoun, et al.
Publicado: (2021)

Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors
por: McClymont, David W., et al.
Publicado: (2012)

The Nucleosome Assembly Protein TSPYL2 Regulates the Expression of NMDA Receptor Subunits GluN2A and GluN2B
por: Tsang, Ka Hing, et al.
Publicado: (2014)

Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
por: Skrenkova, Kristyna, et al.
Publicado: (2019)

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences
por: McKay, Sean, et al.
Publicado: (2018)

GluN2B and GluN2A-containing NMDAR are differentially involved in extinction memory destabilization and restabilization during reconsolidation
por: Radiske, Andressa, et al.
Publicado: (2021)

An Alternating GluN1-2-1-2 Subunit Arrangement in Mature NMDA Receptors
por: Riou, Morgane, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_kvuc44m0694p5gahqdh813vr9s