SOX9 interacts with FOXC1 to activate MYC and regulate CDK7 inhibitor sensitivity in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is particularly sensitive to cyclin-dependent kinase 7 inhibitor, THZ1, compared to hormone receptor (HR)+ breast cancer, but our data found that different TNBC cell lines had a wide range of IC(50) values of THZ1, suggesting a possible heterogeneity in sensitivi...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Lin, Jin, Juan, Xu, Kun, Wang, Xin, Tang, Jinhai, Guan, Xiaoxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217837/
https://www.ncbi.nlm.nih.gov/pubmed/32398735
http://dx.doi.org/10.1038/s41389-020-0232-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217837/
https://www.ncbi.nlm.nih.gov/pubmed/32398735
http://dx.doi.org/10.1038/s41389-020-0232-1

Ejemplares similares