Cargando…

Association of early-onset Alzheimer’s disease with germline-generated high affinity self-antigen load

Self-antigen presentation outside the central nervous system has crucial role regarding self-proteins tolerance and autoimmunity, leading to neuroinflammation. Self-antigen with strong-binding affinity is considered to be pathogenic. We aim to investigate whether strong-binding affinity self-antigen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Poyin, Yang, Yuan-Han, Chang, Ya-Hsuan, Chang, Shu-Ling, Chou, Mei-Chuan, Lai, Chiou-Lian, Liu, Ching-Kuan, Chen, Hsuan-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217838/ https://www.ncbi.nlm.nih.gov/pubmed/32398703 http://dx.doi.org/10.1038/s41398-020-0826-6

Ejemplares similares

REST rs3796529 Genotype and Rate of Functional Deterioration in Alzheimer’s Disease
por: Huang, Poyin, et al.
Publicado: (2019)

Adjunct effect of music therapy on cognition in Alzheimer’s disease in Taiwan: a pilot study
por: Li, Chien-Hsun, et al.
Publicado: (2015)

Molecular gene signature and prognosis of non-small cell lung cancer
por: Huang, Poyin, et al.
Publicado: (2016)

Apolipoprotein E e4 allele is associated with extrapyramidal symptoms in Alzheimer’s disease
por: Chang, Yang-Pei, et al.
Publicado: (2019)

Antiphospholipid syndrome presenting as progressive neuropsychiatric disorders: two case reports
por: Li, Chien-Hsun, et al.
Publicado: (2013)

Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study
por: Chou, Ping-Song, et al.
Publicado: (2014)

Germline rare deleterious variant load alters cancer risk, age of onset and tumor characteristics
por: Esai Selvan, Myvizhi, et al.
Publicado: (2023)

Affinity Purification Coupled to Stable Isotope Dilution LC-MS/MS Analysis to Discover IgG4 Glycosylation Profiles for Autoimmune Pancreatitis
por: Chen, Michael X., et al.
Publicado: (2021)

Efficient Generation of Chemically Induced Mesenchymal Stem Cells from Human Dermal Fibroblasts
por: Lai, Pei-Lun, et al.
Publicado: (2017)

Epigallocatechin-3-Gallate Suppresses Human Herpesvirus 8 Replication and Induces ROS Leading to Apoptosis and Autophagy in Primary Effusion Lymphoma Cells
por: Tsai, Ching-Yi, et al.
Publicado: (2017)

TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer’s Disease
por: Chen, Yi-Chun, et al.
Publicado: (2023)

The Interaction Affinity between Vascular Cell Adhesion Molecule-1 (VCAM-1) and Very Late Antigen-4 (VLA-4) Analyzed by Quantitative FRET
por: Chakraborty, Sandeep, et al.
Publicado: (2015)

Colonization With Multidrug-Resistant Organisms Among Healthy Adults in the Community Setting: Prevalence, Risk Factors, and Composition of Gut Microbiome
por: Huang, Yu-Shan, et al.
Publicado: (2020)

The association between metabolic syndrome and successful aging- using an extended definition of successful aging
por: Lin, Yi-Hsuan, et al.
Publicado: (2021)

Sleep apnea and the subsequent risk of Parkinson’s disease: a 3-year nationwide population-based study
por: Chou, Ping-Song, et al.
Publicado: (2017)

Curcumin-Loaded Hydrophobic Surface-Modified Hydroxyapatite as an Antioxidant for Sarcopenia Prevention
por: Liang, Ya-Jyun, et al.
Publicado: (2021)

Single-nucleotide polymorphism of rs7944135 (macrophage-expressed gene 1) is associated with hepatitis B surface antigen seroclearance in chronic hepatitis B infection: A cohort study
por: Irham, Lalu Muhammad, et al.
Publicado: (2019)

On the Rapid Calculation of Binding Affinities for Antigen and Antibody Design and Affinity Maturation Simulations
por: Conti, Simone, et al.
Publicado: (2022)

DG-Affinity: predicting antigen–antibody affinity with language models from sequences
por: Yuan, Ye, et al.
Publicado: (2023)

Multiplex Immunoassays Utilizing Differential Affinity Using Aptamers Generated by MARAS
por: Lai, Ji-Ching, et al.
Publicado: (2017)

Germline Mutations in Patients With Early-Onset Prostate Cancer
por: Tang, Tang, et al.
Publicado: (2022)

Prefrontal Lobe Brain Reserve Capacity with Resistance to Higher Global Amyloid Load and White Matter Hyperintensity Burden in Mild Stage Alzheimer’s Disease
por: Chang, Ya-Ting, et al.
Publicado: (2016)

Prescription patterns and factors influencing the use of Chinese herbal medicine among pregnant women in Taiwan: a population-based retrospective study
por: Wen, Shu-Hui, et al.
Publicado: (2020)

Government-sponsored disinformation and the severity of respiratory infection epidemics including COVID-19: A global analysis, 2001–2020
por: Lin, Thung-Hong, et al.
Publicado: (2022)

Generation of TCRs of higher affinity by antigen-driven differentiation of progenitor T cells in vitro
por: Schmitt, Thomas M., et al.
Publicado: (2017)

Antigen binding by conformational selection in near-germline antibodies
por: Blackler, Ryan J., et al.
Publicado: (2022)

Hyperbaric Oxygen Therapy Improves Parkinson’s Disease by Promoting Mitochondrial Biogenesis via the SIRT-1/PGC-1α Pathway
por: Hsu, Hung-Te, et al.
Publicado: (2022)

Learned features of antibody-antigen binding affinity
por: Miller, Nathaniel L., et al.
Publicado: (2023)

Relapsing autoimmune inner ear disease with significant response to methotrexate and azathioprine combination therapy: A case report and mini literature review
por: Huang, Kuan-Hsuan, et al.
Publicado: (2023)

Efficacy and Safety of Topiramate for Essential Tremor: A Meta-Analysis of Randomized Controlled Trials
por: Chang, Kuo-Hsuan, et al.
Publicado: (2015)

A Novel Technique for Autograft Preparation Using Patient-Specific Instrumentation (PSI) Assistance in Total Hip Arthroplasty in Developmental Dysplasia of Hip (DDH)
por: Lin, Chun-Ru, et al.
Publicado: (2023)

Increased Risk of Acute Pancreatitis in Patients with Rheumatoid Arthritis: A Population-Based Cohort Study
por: Chang, Chi Ching, et al.
Publicado: (2015)

Germline Mutations of Inhibins in Early-Onset Ovarian Epithelial Tumors
por: Tournier, Isabelle, et al.
Publicado: (2014)

The repertoire of germline variants in patients with early‐onset rectal cancer
por: Beltrami, Caroline Moraes, et al.
Publicado: (2022)

Dose-dependent genotype effects of BDNF Val66Met polymorphism on default mode network in early stage Alzheimer's disease
por: Lin, Pin-Hsuan, et al.
Publicado: (2016)

Long-range hydrogen-bond relay catalyses the excited-state proton transfer reaction
por: Chang, Kai-Hsin, et al.
Publicado: (2023)

Total HLA Class I Antigen Loss with the Downregulation of Antigen-Processing Machinery Components in Two Newly Established Sarcomatoid Hepatocellular Carcinoma Cell Lines
por: Lei, Wei-Yi, et al.
Publicado: (2018)

Pathogenic Germline Mutations of DNA Repair Pathway Components in Early-Onset Sporadic Colorectal Polyp and Cancer Patients
por: Chang, Pi-Yueh, et al.
Publicado: (2020)

Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
por: Lin, Ching-Wen, et al.
Publicado: (2016)

Corrigendum: Daxx inhibits hypoxia-induced lung cancer cell metastasis by suppressing the HIF-1α/HDAC1/Slug axis
por: Lin, Ching-Wen, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_tq9hveu4dg1a7cln1kb9ip9ucf