A direct comparison of selective BH3-mimetics reveals BCL-X(L), BCL-2 and MCL-1 as promising therapeutic targets in neuroblastoma

BACKGROUND: Despite advances in the treatment of neuroblastoma, patients with high-risk disease still have dismal survival prognosis. Neuroblastoma cells display elevated expression of the antiapoptotic BCL-2 proteins, suggesting that BH3-mimetics may be a promising treatment option. Here, we invest...

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Detalles Bibliográficos
Autores principales: Bierbrauer, Annika, Jacob, Maureen, Vogler, Meike, Fulda, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217842/
https://www.ncbi.nlm.nih.gov/pubmed/32203216
http://dx.doi.org/10.1038/s41416-020-0795-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217842/
https://www.ncbi.nlm.nih.gov/pubmed/32203216
http://dx.doi.org/10.1038/s41416-020-0795-9

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