N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease

Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer’s disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl sphingosine (N-AS) is first generated by acetyl-...

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Detalles Bibliográficos
Autores principales: Lee, Ju Youn, Han, Seung Hoon, Park, Min Hee, Song, Im-Sook, Choi, Min-Koo, Yu, Eunsoo, Park, Cheol-Min, Kim, Hee-Jin, Kim, Seung Hyun, Schuchman, Edward H., Jin, Hee Kyung, Bae, Jae-sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217877/
https://www.ncbi.nlm.nih.gov/pubmed/32398649
http://dx.doi.org/10.1038/s41467-020-16080-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217877/
https://www.ncbi.nlm.nih.gov/pubmed/32398649
http://dx.doi.org/10.1038/s41467-020-16080-4

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