Decreased vitamin C uptake mediated by SLC2A3 promotes leukaemia progression and impedes TET2 restoration

BACKGROUND: Vitamin C suppresses leukaemogenesis by modulating Tet methylcytosine dioxygenase (TET) activity. However, its beneficial effect in the treatment of patients with acute myeloid leukaemia (AML) remains controversial. In this study, we aimed to identify a potential predictive biomarker for...

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Detalles Bibliográficos
Autores principales: Liu, Jun, Hong, Junshik, Han, Heejoo, Park, Jihyun, Kim, Dongchan, Park, Hyejoo, Ko, Myunggon, Koh, Youngil, Shin, Dong-Yeop, Yoon, Sung-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217885/
https://www.ncbi.nlm.nih.gov/pubmed/32203209
http://dx.doi.org/10.1038/s41416-020-0788-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217885/
https://www.ncbi.nlm.nih.gov/pubmed/32203209
http://dx.doi.org/10.1038/s41416-020-0788-8

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