Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess

Copper (Cu) is an essential, yet potentially toxic nutrient, as illustrated by inherited diseases of copper deficiency and excess. Elevated expression of the ATP7A Cu exporter is known to confer copper tolerance, however, the contribution of metal-binding metallothioneins is less clear. In this stud...

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Detalles Bibliográficos
Autores principales: Gudekar, Nikita, Shanbhag, Vinit, Wang, Yanfang, Ralle, Martina, Weisman, Gary A., Petris, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217913/
https://www.ncbi.nlm.nih.gov/pubmed/32398691
http://dx.doi.org/10.1038/s41598-020-64521-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217913/
https://www.ncbi.nlm.nih.gov/pubmed/32398691
http://dx.doi.org/10.1038/s41598-020-64521-3

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