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Toll-like receptor signaling in thymic epithelium controls monocyte-derived dendritic cell recruitment and Treg generation

The development of thymic regulatory T cells (Treg) is mediated by Aire-regulated self-antigen presentation on medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), but the cooperation between these cells is still poorly understood. Here we show that signaling through Toll-like recept...

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Detalles Bibliográficos
Autores principales: Vobořil, Matouš, Brabec, Tomáš, Dobeš, Jan, Šplíchalová, Iva, Březina, Jiří, Čepková, Adéla, Dobešová, Martina, Aidarova, Aigerim, Kubovčiak, Jan, Tsyklauri, Oksana, Štěpánek, Ondřej, Beneš, Vladimír, Sedláček, Radislav, Klein, Ludger, Kolář, Michal, Filipp, Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217920/
https://www.ncbi.nlm.nih.gov/pubmed/32398640
http://dx.doi.org/10.1038/s41467-020-16081-3