Vector Copy Distribution at a Single-Cell Level Enhances Analytical Characterization of Gene-Modified Cell Therapies

The ability to deliver transgenes into the human genome using viral vectors is a major enabler of the gene-modified cell therapy field. However, the control of viral transduction is difficult and can lead to product heterogeneity, impacting efficacy and safety, as well as increasing the risk of batc...

Descripción completa

Detalles Bibliográficos
Autores principales: Santeramo, Ilaria, Bagnati, Marta, Harvey, Emily Jane, Hassan, Enas, Surmacz-Cordle, Beata, Marshall, Damian, Di Cerbo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217927/
https://www.ncbi.nlm.nih.gov/pubmed/32420408
http://dx.doi.org/10.1016/j.omtm.2020.04.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217927/
https://www.ncbi.nlm.nih.gov/pubmed/32420408
http://dx.doi.org/10.1016/j.omtm.2020.04.016

Ejemplares similares