Modelling hepatitis D virus RNA and HBsAg dynamics during nucleic acid polymer monotherapy suggest rapid turnover of HBsAg

Hepatitis D virus (HDV) requires hepatitis B surface antigen (HBsAg) for its assembly and release. Current HBV treatments are only marginally effective against HDV because they fail to inhibit HBsAg production/secretion. However, monotherapy with the nucleic acid polymer REP 2139-Ca is accompanied b...

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Detalles Bibliográficos
Autores principales: Shekhtman, Louis, Cotler, Scott J., Hershkovich, Leeor, Uprichard, Susan L., Bazinet, Michel, Pantea, Victor, Cebotarescu, Valentin, Cojuhari, Lilia, Jimbei, Pavlina, Krawczyk, Adalbert, Dittmer, Ulf, Vaillant, Andrew, Dahari, Harel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217939/
https://www.ncbi.nlm.nih.gov/pubmed/32398799
http://dx.doi.org/10.1038/s41598-020-64122-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217939/
https://www.ncbi.nlm.nih.gov/pubmed/32398799
http://dx.doi.org/10.1038/s41598-020-64122-0

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