Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling

One-carbon metabolism fuels the high demand of cancer cells for nucleotides and other building blocks needed for increased proliferation. Although inhibitors of this pathway are widely used to treat many cancers, their global impact on anabolic and catabolic processes remains unclear. Using a combin...

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Detalles Bibliográficos
Autores principales: Papadopoli, David J., Ma, Eric H., Roy, Dominic, Russo, Mariana, Bridon, Gaëlle, Avizonis, Daina, Jones, Russell G., St-Pierre, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217946/
https://www.ncbi.nlm.nih.gov/pubmed/32398698
http://dx.doi.org/10.1038/s41598-020-64460-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217946/
https://www.ncbi.nlm.nih.gov/pubmed/32398698
http://dx.doi.org/10.1038/s41598-020-64460-z

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