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Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling
One-carbon metabolism fuels the high demand of cancer cells for nucleotides and other building blocks needed for increased proliferation. Although inhibitors of this pathway are widely used to treat many cancers, their global impact on anabolic and catabolic processes remains unclear. Using a combin...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217946/ https://www.ncbi.nlm.nih.gov/pubmed/32398698 http://dx.doi.org/10.1038/s41598-020-64460-z |