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EGFR Signaling Causes Morphine Tolerance and Mechanical Sensitization in Rats
The safety and efficacy of opioids are compromised as analgesic tolerance develops. Opioids are also ineffective against neuropathic pain. Recent reports have suggested that inhibitors of the epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), may have analgesic effects in can...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Society for Neuroscience
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218007/ https://www.ncbi.nlm.nih.gov/pubmed/32111605 http://dx.doi.org/10.1523/ENEURO.0460-18.2020 |