The dynamic landscape of BRCA1 reversion mutations from indel to SNV in a patient with ovarian cancer treated with PARP-inhibitors and immunotherapy

BACKGROUND: Reversion mutations of somatic BRCA mutations are an important source of resistance within ovarian cancer. Furthermore, these reversion mutations are known to change over the course of treatment. Better understanding of the mechanisms leading to reversion mutations and the role of serial...

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Detalles Bibliográficos
Autores principales: Jacob, Saya L., Kiedrowski, Lesli A., Chae, Young K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218016/
https://www.ncbi.nlm.nih.gov/pubmed/32420470
http://dx.doi.org/10.1016/j.heliyon.2020.e03841

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218016/
https://www.ncbi.nlm.nih.gov/pubmed/32420470
http://dx.doi.org/10.1016/j.heliyon.2020.e03841

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