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FcγR Binding and ADCC Activity of Human IgG Allotypes

Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly triggered by IgG-subclasses IgG1 and IgG3 through the IgG-Fc-receptor (FcγR) IIIa. Polymorphisms in the immunoglobul...

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Detalles Bibliográficos
Autores principales:	de Taeye, Steven W., Bentlage, Arthur E. H., Mebius, Mirjam M., Meesters, Joyce I., Lissenberg-Thunnissen, Suzanne, Falck, David, Sénard, Thomas, Salehi, Nima, Wuhrer, Manfred, Schuurman, Janine, Labrijn, Aran F., Rispens, Theo, Vidarsson, Gestur
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218058/ https://www.ncbi.nlm.nih.gov/pubmed/32435243 http://dx.doi.org/10.3389/fimmu.2020.00740

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