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Moving to CoPACaPAnA: Implementation of a continuous protein A capture process for antibody applications within an end-to-end single-use GMP manufacturing downstream process
For the first time to our knowledge the implementation of a continuous protein A capture process for antibody applications (CoPACaPAnA) embedded in an end-to-end single-use 500 L GMP manufacturing downstream process of a multispecific monoclonal antibody (mAb) using a single-use SMB system was condu...
Autores principales: | Ötes, Ozan, Bernhardt, Cathrin, Brandt, Kevin, Flato, Hendrik, Klingler, Otmar, Landrock, Katharina, Lohr, Verena, Stähler, Ralf, Capito, Florian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218147/ https://www.ncbi.nlm.nih.gov/pubmed/32420053 http://dx.doi.org/10.1016/j.btre.2020.e00465 |
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