Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. A bifunctional PROTAC molecule consists of a ligand (mostly small-molecule inhibitor) of the protein of interest (POI) and a covalently linked ligand of an E3 ubiquitin ligase (E3)....

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Detalles Bibliográficos
Autores principales: Li, Xin, Song, Yongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218526/
https://www.ncbi.nlm.nih.gov/pubmed/32404196
http://dx.doi.org/10.1186/s13045-020-00885-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218526/
https://www.ncbi.nlm.nih.gov/pubmed/32404196
http://dx.doi.org/10.1186/s13045-020-00885-3

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