C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor

Acute erythroid leukemia (AEL) commonly involves both myeloid and erythroid lineage transformation. However, the mutations that cause AEL and the cell(s) that sustain the bilineage leukemia phenotype remain unknown. We here show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations...

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Detalles Bibliográficos
Autores principales: Di Genua, Cristina, Valletta, Simona, Buono, Mario, Stoilova, Bilyana, Sweeney, Connor, Rodriguez-Meira, Alba, Grover, Amit, Drissen, Roy, Meng, Yiran, Beveridge, Ryan, Aboukhalil, Zahra, Karamitros, Dimitris, Belderbos, Mirjam E., Bystrykh, Leonid, Thongjuea, Supat, Vyas, Paresh, Nerlov, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218711/
https://www.ncbi.nlm.nih.gov/pubmed/32330454
http://dx.doi.org/10.1016/j.ccell.2020.03.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218711/
https://www.ncbi.nlm.nih.gov/pubmed/32330454
http://dx.doi.org/10.1016/j.ccell.2020.03.022

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