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Phospholipid methylation regulates muscle metabolic rate through Ca(2+) transport efficiency

The biophysical environment of membrane phospholipids affects structure, function, and stability of membrane-bound proteins.(1,2) Obesity can disrupt membrane lipids, and in particular, alter the activity of sarco/endoplasmic reticulum (ER/SR) Ca(2+)-ATPase (SERCA) to affect cellular metabolism.(3–5...

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Detalles Bibliográficos
Autores principales: Verkerke, Anthony R.P., Ferrara, Patrick J., Lin, Chien-Te, Johnson, Jordan M., Ryan, Terence E., Maschek, J. Alan, Eshima, Hiroaki, Paran, Christopher W., Laing, Brenton T., Siripoksup, Piyarat, Tippetts, Trevor S., Wentzler, Edward J., Huang, Hu, Spangenburg, Espen. E., Brault, Jeffrey J., Villanueva, Claudio J., Summers, Scott A., Holland, William L., Cox, James E., Vance, Dennis E., Neufer, P. Darrell, Funai, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218817/
https://www.ncbi.nlm.nih.gov/pubmed/32405618
http://dx.doi.org/10.1038/s42255-019-0111-2