Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types

Recombinant adeno-associated viruses (rAAVs) are efficient, non-invasive gene delivery vectors via intravenous delivery, however, natural serotypes display a finite set of tropisms. To expand their utility, we evolved AAV capsids to efficiently transduce specific cell types in adult mouse brains. Bu...

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Detalles Bibliográficos
Autores principales: Kumar, Sripriya Ravindra, Miles, Timothy F., Chen, Xinhong, Brown, David, Dobreva, Tatyana, Huang, Qin, Ding, Xiaozhe, Luo, Yicheng, Einarsson, Pétur H., Greenbaum, Alon, Jang, Min J., Deverman, Benjamin E., Gradinaru, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219404/
https://www.ncbi.nlm.nih.gov/pubmed/32313222
http://dx.doi.org/10.1038/s41592-020-0799-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219404/
https://www.ncbi.nlm.nih.gov/pubmed/32313222
http://dx.doi.org/10.1038/s41592-020-0799-7

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