Association between blood lipid level and embryo quality during in vitro fertilization

The aim of this study was to investigate the relationship between blood lipid level and the parameters of embryo morphology of in vitro fertilization (IVF). A total of 488 patients undergoing conventional IVF were divided into pregnant (n = 286) and nonpregnant (n = 202) groups. Levels of triglyceri...

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Autores principales: Wang, Shanshan, Wang, Jun, Jiang, Yiqun, Jiang, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220153/
https://www.ncbi.nlm.nih.gov/pubmed/32221094
http://dx.doi.org/10.1097/MD.0000000000019665
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author Wang, Shanshan
Wang, Jun
Jiang, Yiqun
Jiang, Weihua
author_facet Wang, Shanshan
Wang, Jun
Jiang, Yiqun
Jiang, Weihua
author_sort Wang, Shanshan
collection PubMed
description The aim of this study was to investigate the relationship between blood lipid level and the parameters of embryo morphology of in vitro fertilization (IVF). A total of 488 patients undergoing conventional IVF were divided into pregnant (n = 286) and nonpregnant (n = 202) groups. Levels of triglycerides (TG), total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoprotein (LDL), lipoprotein (a), lipoprotein (b), and embryo outcomes were studied. Spearman correlation was performed to analyze the correlation between blood lipid levels and embryo quality in pregnant group. The normal fertilization rate and number of good quality embryos were higher than nonpregnant group (P < .05). TG, TC, and LDL levels were negatively correlated with number of normal fertilized oocytes, while TG, TC, and Lp(b) were negatively correlated with number of good quality embryos. TG level was negatively correlated with number of oocytes and cleavage embryos while HDL and Lp(a) were positively correlated with number of oocytes, normal fertilized oocytes and cleavage embryos (P < .05). TG, TC, LDL, and Lp(b) levels had negative correlation with embryo quality, while HDL and Lp(a) had positive correlation with the embryo quality. Our present findings showed blood lipid levels may provide certain reference for the prediction of IVF pregnancy outcome.
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spelling pubmed-72201532020-06-15 Association between blood lipid level and embryo quality during in vitro fertilization Wang, Shanshan Wang, Jun Jiang, Yiqun Jiang, Weihua Medicine (Baltimore) 5600 The aim of this study was to investigate the relationship between blood lipid level and the parameters of embryo morphology of in vitro fertilization (IVF). A total of 488 patients undergoing conventional IVF were divided into pregnant (n = 286) and nonpregnant (n = 202) groups. Levels of triglycerides (TG), total cholesterol (TC), high-density lipoproteins (HDL), low-density lipoprotein (LDL), lipoprotein (a), lipoprotein (b), and embryo outcomes were studied. Spearman correlation was performed to analyze the correlation between blood lipid levels and embryo quality in pregnant group. The normal fertilization rate and number of good quality embryos were higher than nonpregnant group (P < .05). TG, TC, and LDL levels were negatively correlated with number of normal fertilized oocytes, while TG, TC, and Lp(b) were negatively correlated with number of good quality embryos. TG level was negatively correlated with number of oocytes and cleavage embryos while HDL and Lp(a) were positively correlated with number of oocytes, normal fertilized oocytes and cleavage embryos (P < .05). TG, TC, LDL, and Lp(b) levels had negative correlation with embryo quality, while HDL and Lp(a) had positive correlation with the embryo quality. Our present findings showed blood lipid levels may provide certain reference for the prediction of IVF pregnancy outcome. Wolters Kluwer Health 2020-03-27 /pmc/articles/PMC7220153/ /pubmed/32221094 http://dx.doi.org/10.1097/MD.0000000000019665 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 5600
Wang, Shanshan
Wang, Jun
Jiang, Yiqun
Jiang, Weihua
Association between blood lipid level and embryo quality during in vitro fertilization
title Association between blood lipid level and embryo quality during in vitro fertilization
title_full Association between blood lipid level and embryo quality during in vitro fertilization
title_fullStr Association between blood lipid level and embryo quality during in vitro fertilization
title_full_unstemmed Association between blood lipid level and embryo quality during in vitro fertilization
title_short Association between blood lipid level and embryo quality during in vitro fertilization
title_sort association between blood lipid level and embryo quality during in vitro fertilization
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220153/
https://www.ncbi.nlm.nih.gov/pubmed/32221094
http://dx.doi.org/10.1097/MD.0000000000019665
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