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Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice

Dipeptidyl peptidase 4 (DPP-4) inhibitors exert pleiotropic effects beyond glycemic control. We investigated the renoprotective effects of DPP-4 inhibitors on aging mice mediated by the renin-angiotensin system (RAS). C57BL/6 mice were divided into three groups: the two-month-old mice (YM group), th...

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Autores principales: Ban, Tae H, Kim, Eun N, Kim, Min Y, Lim, Ji H, Lee, Jong H, Kim, Hyung D, Yoon, Hye E, Park, Cheol W, Choi, Bum S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220286/
https://www.ncbi.nlm.nih.gov/pubmed/32489704
http://dx.doi.org/10.14336/AD.2019.0620
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author Ban, Tae H
Kim, Eun N
Kim, Min Y
Lim, Ji H
Lee, Jong H
Kim, Hyung D
Yoon, Hye E
Park, Cheol W
Choi, Bum S
author_facet Ban, Tae H
Kim, Eun N
Kim, Min Y
Lim, Ji H
Lee, Jong H
Kim, Hyung D
Yoon, Hye E
Park, Cheol W
Choi, Bum S
author_sort Ban, Tae H
collection PubMed
description Dipeptidyl peptidase 4 (DPP-4) inhibitors exert pleiotropic effects beyond glycemic control. We investigated the renoprotective effects of DPP-4 inhibitors on aging mice mediated by the renin-angiotensin system (RAS). C57BL/6 mice were divided into three groups: the two-month-old mice (YM group), the eighteen-month-old mice (AM group) and the eighteen-month-old, linagliptin-treated mice (AM + LIN group). Renal function was improved, based on serum creatinine and cystatin-C levels (p < 0.05 compared with the AM group for both parameters). Fibrotic areas and the levels of proteins related to fibrosis improved in the AM + LIN group (p < 0.001 compared with the AM group for all parameters). In the AM + LIN group, the DPP-4-positive area and activity and expressions of DPP-4 were decreased (p < 0.05 compared with the AM group for all parameters). The levels of proteins related to the RAS, including prorenin receptor, angiotensin-converting enzyme, angiotensin II and angiotensin 1 receptor, were decreased in the AM + LIN group (p < 0.05, p < 0.01, p < 0.05, and p < 0.01 compared with the AM group, respectively). NADPH oxidase 2 and NADPH oxidase 4 levels decreased in the AM + LIN group (p < 0.001 compared with the AM group for both proteins), whereas the levels of endothelial nitric oxide synthase (eNOS) phosphorylated at serine(1177) and superoxide dismutase 1 were increased (p < 0.01 compared with the AM group for both proteins). DPP-4 inhibitors may exert renoprotective effects via prorenin receptor/angiotensin-converting enzyme/angiotensin II/angiotensin 1 receptor axis.
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spelling pubmed-72202862020-06-01 Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice Ban, Tae H Kim, Eun N Kim, Min Y Lim, Ji H Lee, Jong H Kim, Hyung D Yoon, Hye E Park, Cheol W Choi, Bum S Aging Dis Orginal Article Dipeptidyl peptidase 4 (DPP-4) inhibitors exert pleiotropic effects beyond glycemic control. We investigated the renoprotective effects of DPP-4 inhibitors on aging mice mediated by the renin-angiotensin system (RAS). C57BL/6 mice were divided into three groups: the two-month-old mice (YM group), the eighteen-month-old mice (AM group) and the eighteen-month-old, linagliptin-treated mice (AM + LIN group). Renal function was improved, based on serum creatinine and cystatin-C levels (p < 0.05 compared with the AM group for both parameters). Fibrotic areas and the levels of proteins related to fibrosis improved in the AM + LIN group (p < 0.001 compared with the AM group for all parameters). In the AM + LIN group, the DPP-4-positive area and activity and expressions of DPP-4 were decreased (p < 0.05 compared with the AM group for all parameters). The levels of proteins related to the RAS, including prorenin receptor, angiotensin-converting enzyme, angiotensin II and angiotensin 1 receptor, were decreased in the AM + LIN group (p < 0.05, p < 0.01, p < 0.05, and p < 0.01 compared with the AM group, respectively). NADPH oxidase 2 and NADPH oxidase 4 levels decreased in the AM + LIN group (p < 0.001 compared with the AM group for both proteins), whereas the levels of endothelial nitric oxide synthase (eNOS) phosphorylated at serine(1177) and superoxide dismutase 1 were increased (p < 0.01 compared with the AM group for both proteins). DPP-4 inhibitors may exert renoprotective effects via prorenin receptor/angiotensin-converting enzyme/angiotensin II/angiotensin 1 receptor axis. JKL International LLC 2019-06-20 /pmc/articles/PMC7220286/ /pubmed/32489704 http://dx.doi.org/10.14336/AD.2019.0620 Text en Copyright: © 2020 Ban et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Orginal Article
Ban, Tae H
Kim, Eun N
Kim, Min Y
Lim, Ji H
Lee, Jong H
Kim, Hyung D
Yoon, Hye E
Park, Cheol W
Choi, Bum S
Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice
title Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice
title_full Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice
title_fullStr Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice
title_full_unstemmed Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice
title_short Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice
title_sort renoprotective effect of a dipeptidyl peptidase-4 inhibitor on aging mice
topic Orginal Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220286/
https://www.ncbi.nlm.nih.gov/pubmed/32489704
http://dx.doi.org/10.14336/AD.2019.0620
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