Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos

It has not been possible to generate naïve human pluripotent stem cells (hPSCs) that substantially contribute to mouse embryos. We found that a brief inhibition of mTOR with Torin1 converted hPSCs from primed to naïve pluripotency. The naïve hPSCs were maintained in the same condition as mouse embry...

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Detalles Bibliográficos
Autores principales: Hu, Zhixing, Li, Hanqin, Jiang, Houbo, Ren, Yong, Yu, Xinyang, Qiu, Jingxin, Stablewski, Aimee B., Zhang, Boyang, Buck, Michael J., Feng, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220352/
https://www.ncbi.nlm.nih.gov/pubmed/32426495
http://dx.doi.org/10.1126/sciadv.aaz0298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220352/
https://www.ncbi.nlm.nih.gov/pubmed/32426495
http://dx.doi.org/10.1126/sciadv.aaz0298

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