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Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos
It has not been possible to generate naïve human pluripotent stem cells (hPSCs) that substantially contribute to mouse embryos. We found that a brief inhibition of mTOR with Torin1 converted hPSCs from primed to naïve pluripotency. The naïve hPSCs were maintained in the same condition as mouse embry...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220352/ https://www.ncbi.nlm.nih.gov/pubmed/32426495 http://dx.doi.org/10.1126/sciadv.aaz0298 |