Chromatin Regulators Mediate Anthracycline Sensitivity in Breast Cancer

Anthracyclines are a highly effective component of curative breast cancer chemotherapy, but are associated with significant morbidity(1,2). Since anthracyclines work in part via inhibition of topoisomerase-II (TOP2) on accessible DNA(3,4), we hypothesized that chromatin regulatory genes (CRGs) that...

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Detalles Bibliográficos
Autores principales: Seoane, Jose A., Kirkland, Jacob G., Caswell-Jin, Jennifer L., Crabtree, Gerald R., Curtis, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220800/
https://www.ncbi.nlm.nih.gov/pubmed/31700186
http://dx.doi.org/10.1038/s41591-019-0638-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220800/
https://www.ncbi.nlm.nih.gov/pubmed/31700186
http://dx.doi.org/10.1038/s41591-019-0638-5

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