Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression

The genetically heterogeneous triple-negative breast cancer (TNBC) continues to be an intractable disease, due to lack of effective targeted therapies. Gene amplification is a major event in tumorigenesis. Genes with amplification-dependent expression are being explored as therapeutic targets for ca...

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Detalles Bibliográficos
Autores principales: He, Jichao, McLaughlin, Ronan P., van der Beek, Lambert, Canisius, Sander, Wessels, Lodewyk, Smid, Marcel, Martens, John W. M., Foekens, John A., Zhang, Yinghui, van de Water, Bob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220851/
https://www.ncbi.nlm.nih.gov/pubmed/32235890
http://dx.doi.org/10.1038/s41388-020-1279-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220851/
https://www.ncbi.nlm.nih.gov/pubmed/32235890
http://dx.doi.org/10.1038/s41388-020-1279-3

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