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ER stress activates immunosuppressive network: implications for aging and Alzheimer’s disease

The endoplasmic reticulum (ER) contains stress sensors which recognize the accumulation of unfolded proteins within the lumen of ER, and subsequently these transducers stimulate the unfolded protein response (UPR). The ER sensors include the IRE1, PERK, and ATF6 transducers which activate the UPR in...

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Detalles Bibliográficos
Autores principales: Salminen, Antero, Kaarniranta, Kai, Kauppinen, Anu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220864/
https://www.ncbi.nlm.nih.gov/pubmed/32279085
http://dx.doi.org/10.1007/s00109-020-01904-z