LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages

The Parkinson's disease-associated gene, LRRK2, is also associated with immune disorders and infectious disease and is expressed in immune subsets. Here, we characterize a platform for interrogating the expression and function of endogenous LRRK2 in authentic human phagocytes using human induce...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Heyne, Flynn, Rowan, Sharma, Ishta, Haberman, Emma, Carling, Phillippa J., Nicholls, Francesca J., Stegmann, Monika, Vowles, Jane, Haenseler, Walther, Wade-Martins, Richard, James, William S., Cowley, Sally A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221108/
https://www.ncbi.nlm.nih.gov/pubmed/32359446
http://dx.doi.org/10.1016/j.stemcr.2020.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221108/
https://www.ncbi.nlm.nih.gov/pubmed/32359446
http://dx.doi.org/10.1016/j.stemcr.2020.04.001

Ejemplares similares