Intrapulmonary (i.pulmon.) Pull Immunization With the Tuberculosis Subunit Vaccine Candidate H56/CAF01 After Intramuscular (i.m.) Priming Elicits a Distinct Innate Myeloid Response and Activation of Antigen-Presenting Cells Than i.m. or i.pulmon. Prime Immunization Alone

Understanding the in vivo fate of vaccine antigens and adjuvants and their safety is crucial for the rational design of mucosal subunit vaccines. Prime and pull vaccination using the T helper 17-inducing adjuvant CAF01 administered parenterally and mucosally, respectively, has previously been sugges...

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Autores principales:	Thakur, Aneesh, Pinto, Fernanda Endringer, Hansen, Harald Severin, Andersen, Peter, Christensen, Dennis, Janfelt, Christian, Foged, Camilla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221191/ https://www.ncbi.nlm.nih.gov/pubmed/32457748 http://dx.doi.org/10.3389/fimmu.2020.00803