Development of a Selection Method for Discovering Irreversible (Covalent) Binders from a DNA-Encoded Library

DNA-encoded libraries (DELs) have been broadly applied to identify chemical probes for target validation and lead discovery. To date, the main application of the DEL platform has been the identification of reversible ligands using multiple rounds of affinity selection. Irreversible (covalent) inhibi...

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Detalles Bibliográficos
Autores principales: Zhu, Zhengrong, Grady, LaShadric C., Ding, Yun, Lind, Kenneth E., Davie, Christopher P., Phelps, Christopher B., Evindar, Ghotas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221453/
https://www.ncbi.nlm.nih.gov/pubmed/30383465
http://dx.doi.org/10.1177/2472555218808454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221453/
https://www.ncbi.nlm.nih.gov/pubmed/30383465
http://dx.doi.org/10.1177/2472555218808454

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