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Development of a Selection Method for Discovering Irreversible (Covalent) Binders from a DNA-Encoded Library
DNA-encoded libraries (DELs) have been broadly applied to identify chemical probes for target validation and lead discovery. To date, the main application of the DEL platform has been the identification of reversible ligands using multiple rounds of affinity selection. Irreversible (covalent) inhibi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
SAGE Publications
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221453/ https://www.ncbi.nlm.nih.gov/pubmed/30383465 http://dx.doi.org/10.1177/2472555218808454 |