Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents

Colchicine is a well-known compound with strong antiproliferative activity that has had limited use in chemotherapy because of its toxicity. In order to create more potent anticancer agents, a series of novel colchicine derivatives have been obtained by simultaneous modification at C7 (amides and su...

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Detalles Bibliográficos
Autores principales: Krzywik, Julia, Mozga, Witold, Aminpour, Maral, Janczak, Jan, Maj, Ewa, Wietrzyk, Joanna, Tuszyński, Jack A., Huczyński, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221574/
https://www.ncbi.nlm.nih.gov/pubmed/32295119
http://dx.doi.org/10.3390/molecules25081789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221574/
https://www.ncbi.nlm.nih.gov/pubmed/32295119
http://dx.doi.org/10.3390/molecules25081789

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