Cargando…

Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents

Colchicine is a well-known compound with strong antiproliferative activity that has had limited use in chemotherapy because of its toxicity. In order to create more potent anticancer agents, a series of novel colchicine derivatives have been obtained by simultaneous modification at C7 (amides and su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krzywik, Julia, Mozga, Witold, Aminpour, Maral, Janczak, Jan, Maj, Ewa, Wietrzyk, Joanna, Tuszyński, Jack A., Huczyński, Adam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221574/ https://www.ncbi.nlm.nih.gov/pubmed/32295119 http://dx.doi.org/10.3390/molecules25081789

Ejemplares similares

New Series of Double-Modified Colchicine Derivatives: Synthesis, Cytotoxic Effect and Molecular Docking
por: Krzywik, Julia, et al.
Publicado: (2020)

Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives
por: Majcher, Urszula, et al.
Publicado: (2018)

Novel Double-Modified Colchicine Derivatives Bearing 1,2,3-Triazole: Design, Synthesis, and Biological Activity Evaluation
por: Krzywik, Julia, et al.
Publicado: (2021)

Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine
por: Czerwonka, Dominika, et al.
Publicado: (2020)

Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides
por: Antoszczak, Michał, et al.
Publicado: (2014)

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
por: Majcher, Urszula, et al.
Publicado: (2018)

Photoinduced Skeletal Rearrangement of N-Substituted Colchicine Derivatives
por: Czerwonka, Dominika, et al.
Publicado: (2020)

Synthesis and Anticancer Activity of Dimeric Polyether Ionophores
por: Sulik, Michał, et al.
Publicado: (2020)

Biaryl Sulfonamides Based on the 2-Azabicycloalkane Skeleton—Synthesis and Antiproliferative Activity
por: Iwan, Dominika, et al.
Publicado: (2020)

The Antiproliferative and Apoptotic Effects of a Novel Quinazoline Carrying Substituted-Sulfonamides: In Vitro and Molecular Docking Study
por: Alqahtani, Ali S., et al.
Publicado: (2022)

An Overview of Molecular Modeling for Drug Discovery with Specific Illustrative Examples of Applications
por: Aminpour, Maral, et al.
Publicado: (2019)

How COVID-19 Hijacks the Cytoskeleton: Therapeutic Implications
por: Aminpour, Maral, et al.
Publicado: (2022)

Novel Sulfonamide–Triazine Hybrid Derivatives: Docking, Synthesis, and Biological Evaluation as Anticancer Agents
por: Alelaimat, Mahmoud A., et al.
Publicado: (2023)

Design, synthesis, and molecular docking studies of N-substituted sulfonamides as potential anticancer therapeutics
por: Babalola, Ibrahim T., et al.
Publicado: (2023)

Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies
por: Ammazzalorso, Alessandra, et al.
Publicado: (2020)

In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand
por: Pallante, Lorenzo, et al.
Publicado: (2020)

1,2,4-Triazine Sulfonamides: Synthesis by Sulfenamide Intermediates, In Vitro Anticancer Screening, Structural Characterization, and Molecular Docking Study
por: Branowska, Danuta, et al.
Publicado: (2020)

Catalytic amidation of natural and synthetic polyol esters with sulfonamides
por: Liu, Hua, et al.
Publicado: (2019)

Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes
por: Zhao, Fei, et al.
Publicado: (2019)

Isoprenoid-phospholipid conjugates as potential therapeutic agents: Synthesis, characterization and antiproliferative studies
por: Gliszczyńska, Anna, et al.
Publicado: (2017)

Design, synthesis and biological evaluation of tetrahydroquinoxaline sulfonamide derivatives as colchicine binding site inhibitors
por: Dong, Haiyang, et al.
Publicado: (2023)

Computational Analysis and Experimental Testing of the Molecular Mode of Action of Gatastatin and Its Derivatives
por: Vottero, Paola, et al.
Publicado: (2023)

Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies
por: Brito, Vanessa, et al.
Publicado: (2022)

Antiproliferative Activity of New Pyrazole-4-sulfonamide Derivatives: Synthesis and Biological Evaluation
por: Mahesh, Panasa, et al.
Publicado: (2023)

Synthesis and Biological Evaluation of Novel Phosphatidylcholine Analogues Containing Monoterpene Acids as Potent Antiproliferative Agents
por: Gliszczyńska, Anna, et al.
Publicado: (2016)

Supramolecular synthon hierarchy in sulfonamide cocrystals with syn-amides and N-oxides
por: Bolla, Geetha, et al.
Publicado: (2019)

Coumarin Sulfonamides and Amides Derivatives: Design, Synthesis, and Antitumor Activity In Vitro
por: Zhang, Jing, et al.
Publicado: (2021)

Sulfonamide as amide isostere for fine-tuning the gelation properties of physical gels
por: Alegre-Requena, Juan V., et al.
Publicado: (2020)

Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation
por: Ashraf, Zaman, et al.
Publicado: (2019)

Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking
por: Ghorab, Mostafa M., et al.
Publicado: (2017)

Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines
por: Boryczka, Stanisław, et al.
Publicado: (2010)

Antiproliferative benzothiazoles incorporating a trimethoxyphenyl scaffold as novel colchicine site tubulin polymerisation inhibitors
por: Fu, Dong-Jun, et al.
Publicado: (2020)

Synthesis and Antiproliferative Activity of Triazoles Based on 2-Azabicycloalkanes
por: Steppeler, Franz, et al.
Publicado: (2021)

Electrochemical C−H Amidation of Heteroarenes with N‐Alkyl Sulfonamides in Aqueous Medium
por: Zhang, Yan, et al.
Publicado: (2020)

Anticancer Effects with Molecular Docking Confirmation of Newly Synthesized Isatin Sulfonamide Molecular Hybrid Derivatives against Hepatic Cancer Cell Lines
por: Eldeeb, Mahmoud, et al.
Publicado: (2022)

Designing metal chelates of halogenated sulfonamide Schiff bases as potent nonplatinum anticancer drugs using spectroscopic, molecular docking and biological studies
por: Elsamra, Rehab M. I., et al.
Publicado: (2022)

Vitamin D derivatives potentiate the anticancer and anti-angiogenic activity of tyrosine kinase inhibitors in combination with cytostatic drugs in an A549 non-small cell lung cancer model
por: Maj, Ewa, et al.
Publicado: (2017)

Computational Prediction of the Interaction of Ivermectin with Fibrinogen
por: Vottero, Paola, et al.
Publicado: (2023)

Synthesis and Antiproliferative Activity of Minor Hops Prenylflavonoids and New Insights on Prenyl Group Cyclization
por: Popłoński, Jarosław, et al.
Publicado: (2018)

Co-Delivery System of Curcumin and Colchicine Using Functionalized Mesoporous Silica Nanoparticles Promotes Anticancer and Apoptosis Effects
por: AbouAitah, Khaled, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_munasv7l21dq2fotfec3vj3esk