Development of a Rapid Mass Spectrometric Determination of AMP and Cyclic AMP for PDE3 Activity Study: Application and Computational Analysis for Evaluating the Effect of a Novel 2-oxo-1,2-dihydropyridine-3-carbonitrile Derivative as PDE-3 Inhibitor

A simple, quick, easy and cheap tandem mass spectrometry (MS/MS) method for the determination of adenosine monophosphate (AMP) and cyclic adenosine monophosphate (cAMP) has been newly developed. This novel MS/MS method was applied for the evaluation of the inhibitory effect of a novel 2-oxo-1,2-dihy...

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Detalles Bibliográficos
Autores principales: Cicalini, Ilaria, De Filippis, Barbara, Gambacorta, Nicola, Di Michele, Antonio, Valentinuzzi, Silvia, Ammazzalorso, Alessandra, Della Valle, Alice, Amoroso, Rosa, Nicolotti, Orazio, Del Boccio, Piero, Giampietro, Letizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221589/
https://www.ncbi.nlm.nih.gov/pubmed/32326556
http://dx.doi.org/10.3390/molecules25081817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221589/
https://www.ncbi.nlm.nih.gov/pubmed/32326556
http://dx.doi.org/10.3390/molecules25081817

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