Structure–Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation

Recently, we have shown that harmine induces β-cell proliferation both in vitro and in vivo, mediated via the DYRK1A-NFAT pathway. We explore structure–activity relationships of the 7-position of harmine for both DYRK1A kinase inhibition and β-cell proliferation based on our related previous structu...

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Detalles Bibliográficos
Autores principales: Kumar, Kunal, Wang, Peng, A. Swartz, Ethan, Khamrui, Susmita, Secor, Cody, B. Lazarus, Michael, Sanchez, Roberto, F. Stewart, Andrew, DeVita, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221803/
https://www.ncbi.nlm.nih.gov/pubmed/32340326
http://dx.doi.org/10.3390/molecules25081983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221803/
https://www.ncbi.nlm.nih.gov/pubmed/32340326
http://dx.doi.org/10.3390/molecules25081983

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