Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors

Histone deacetylases (HDACs) are a class of epigenetic modulators overexpressed in numerous types of cancers. Consequently, HDAC inhibitors (HDACIs) have emerged as promising antineoplastic agents. Unfortunately, the most developed HDACIs suffer from poor selectivity towards a specific isoform, limi...

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Detalles Bibliográficos
Autores principales: Sirous, Hajar, Campiani, Giuseppe, Brogi, Simone, Calderone, Vincenzo, Chemi, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221830/
https://www.ncbi.nlm.nih.gov/pubmed/32331470
http://dx.doi.org/10.3390/molecules25081952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221830/
https://www.ncbi.nlm.nih.gov/pubmed/32331470
http://dx.doi.org/10.3390/molecules25081952

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