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Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors
Histone deacetylases (HDACs) are a class of epigenetic modulators overexpressed in numerous types of cancers. Consequently, HDAC inhibitors (HDACIs) have emerged as promising antineoplastic agents. Unfortunately, the most developed HDACIs suffer from poor selectivity towards a specific isoform, limi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221830/ https://www.ncbi.nlm.nih.gov/pubmed/32331470 http://dx.doi.org/10.3390/molecules25081952 |