Trimeric Small Interfering RNAs and Their Cholesterol-Containing Conjugates Exhibit Improved Accumulation in Tumors, but Dramatically Reduced Silencing Activity

Cholesterol derivatives of nuclease-resistant, anti-MDR1 small-interfering RNAs were designed to contain a 2’-OMe-modified 21-bp siRNA and a 63-bp TsiRNA in order to investigate their accumulation and silencing activity in vitro and in vivo. The results showed that increasing the length of the RNA d...

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Detalles Bibliográficos
Autores principales: Chernikov, Ivan V., Gladkikh, Daniil V., Karelina, Ulyana A., Meschaninova, Mariya I., Ven’yaminova, Alya G., Vlassov, Valentin V., Chernolovskaya, Elena L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221888/
https://www.ncbi.nlm.nih.gov/pubmed/32325757
http://dx.doi.org/10.3390/molecules25081877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221888/
https://www.ncbi.nlm.nih.gov/pubmed/32325757
http://dx.doi.org/10.3390/molecules25081877

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