Metabolic-Hydroxy and Carboxy Functionalization of Alkyl Moieties in Drug Molecules: Prediction of Structure Influence and Pharmacologic Activity

Alkyl moieties—open chain or cyclic, linear, or branched—are common in drug molecules. The hydrophobicity of alkyl moieties in drug molecules is modified by metabolic hydroxy functionalization via free-radical intermediates to give primary, secondary, or tertiary alcohols depending on the class of t...

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Detalles Bibliográficos
Autores principales: El-Haj, Babiker M., Ahmed, Samrein B.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222001/
https://www.ncbi.nlm.nih.gov/pubmed/32331223
http://dx.doi.org/10.3390/molecules25081937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222001/
https://www.ncbi.nlm.nih.gov/pubmed/32331223
http://dx.doi.org/10.3390/molecules25081937

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