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Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS
Mutations in the FUS gene cause a subset of ALS cases (ALS-FUS). The majority of FUS mutations are missense mutations affecting the nuclear localisation signal (NLS) of FUS. In addition, a number of frameshift mutations which result in complete NLS deletion have been described. Patients bearing fram...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222445/ https://www.ncbi.nlm.nih.gov/pubmed/32404191 http://dx.doi.org/10.1186/s13041-020-00618-0 |