Haplotype-aware graph indexes

MOTIVATION: The variation graph toolkit (VG) represents genetic variation as a graph. Although each path in the graph is a potential haplotype, most paths are non-biological, unlikely recombinations of true haplotypes. RESULTS: We augment the VG model with haplotype information to identify which pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Sirén, Jouni, Garrison, Erik, Novak, Adam M, Paten, Benedict, Durbin, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223266/
https://www.ncbi.nlm.nih.gov/pubmed/31406990
http://dx.doi.org/10.1093/bioinformatics/btz575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223266/
https://www.ncbi.nlm.nih.gov/pubmed/31406990
http://dx.doi.org/10.1093/bioinformatics/btz575

Ejemplares similares