Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase

ABSTRACT: The most effective treatment of Parkinson’s disease is restoring central dopamine levels with levodopa, the metabolic precursor of dopamine. However, due to extensive peripheral metabolism by aromatic l-amino acid decarboxylase and catechol-O-methyltransferase (COMT), only a fraction of th...

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Detalles Bibliográficos
Autores principales: de Beer, Johannie, Petzer, Jacobus P., Lourens, Anna C. U., Petzer, Anél
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224104/
https://www.ncbi.nlm.nih.gov/pubmed/32108308
http://dx.doi.org/10.1007/s11030-020-10053-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224104/
https://www.ncbi.nlm.nih.gov/pubmed/32108308
http://dx.doi.org/10.1007/s11030-020-10053-x

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