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Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase

ABSTRACT: The most effective treatment of Parkinson’s disease is restoring central dopamine levels with levodopa, the metabolic precursor of dopamine. However, due to extensive peripheral metabolism by aromatic l-amino acid decarboxylase and catechol-O-methyltransferase (COMT), only a fraction of th...

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Detalles Bibliográficos
Autores principales:	de Beer, Johannie, Petzer, Jacobus P., Lourens, Anna C. U., Petzer, Anél
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224104/ https://www.ncbi.nlm.nih.gov/pubmed/32108308 http://dx.doi.org/10.1007/s11030-020-10053-x

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