Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

DNA inter-strand crosslinks (ICLs) threaten genomic stability by creating a physical barrier to DNA replication and transcription. ICLs can be caused by endogenous reactive metabolites or from chemotherapeutics. ICL repair in humans depends heavily on the Fanconi Anaemia (FA) pathway. A key signalli...

Descripción completa

Detalles Bibliográficos
Autores principales: Sharp, Michael F., Murphy, Vince J., Twest, Sylvie Van, Tan, Winnie, Lui, Jennii, Simpson, Kaylene J., Deans, Andrew J., Crismani, Wayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224301/
https://www.ncbi.nlm.nih.gov/pubmed/32409752
http://dx.doi.org/10.1038/s41598-020-64868-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224301/
https://www.ncbi.nlm.nih.gov/pubmed/32409752
http://dx.doi.org/10.1038/s41598-020-64868-7

Ejemplares similares