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Methodology for the identification of small molecule inhibitors of the Fanconi Anaemia ubiquitin E3 ligase complex

DNA inter-strand crosslinks (ICLs) threaten genomic stability by creating a physical barrier to DNA replication and transcription. ICLs can be caused by endogenous reactive metabolites or from chemotherapeutics. ICL repair in humans depends heavily on the Fanconi Anaemia (FA) pathway. A key signalli...

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Detalles Bibliográficos
Autores principales:	Sharp, Michael F., Murphy, Vince J., Twest, Sylvie Van, Tan, Winnie, Lui, Jennii, Simpson, Kaylene J., Deans, Andrew J., Crismani, Wayne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224301/ https://www.ncbi.nlm.nih.gov/pubmed/32409752 http://dx.doi.org/10.1038/s41598-020-64868-7

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