Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix

Estragole, naturally occurring in a variety of herbs and spices, can form DNA adducts after bioactivation. Estragole DNA adduct formation and repair was studied in in vitro liver cell models, and a molecular dynamics simulation was used to investigate the conformation dependent (in)efficiency of N(2...

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Detalles Bibliográficos
Autores principales: Yang, Shuo, Diem, Matthias, Liu, Jakob D. H., Wesseling, Sebastiaan, Vervoort, Jacques, Oostenbrink, Chris, Rietjens, Ivonne M. C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225201/
https://www.ncbi.nlm.nih.gov/pubmed/32185416
http://dx.doi.org/10.1007/s00204-020-02695-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225201/
https://www.ncbi.nlm.nih.gov/pubmed/32185416
http://dx.doi.org/10.1007/s00204-020-02695-5

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