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pHLuc, a Ratiometric Luminescent Reporter for in vivo Monitoring of Tumor Acidosis
Even under normoxia, cancer cells exhibit increased glucose uptake and glycolysis, an occurrence known as the Warburg effect. This altered metabolism results in increased lactic acid production, leading to extracellular acidosis and contributing to metastasis and chemoresistance. Current pH imaging...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225611/ https://www.ncbi.nlm.nih.gov/pubmed/32457886 http://dx.doi.org/10.3389/fbioe.2020.00412 |